Cell Death Antibodies 1
Anti-Caspase-10 Antibody (CAB0169)
(No reviews yet)
Write a Review
- SKU:
- CAB0169
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Caspase-10 Antibody |
| Antibody SKU: | CAB0169 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-505 of human Caspase-10 (NP_116759.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-505 of human Caspase-10 (NP_116759.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESWQ NKHA GSNG NRAT NGAP SLVS RGMQ GASA NTLN SETS TKRA AVYR MNRN HRGL CVIV NNHS FTSL KDRQ GTHK DAEI LSHV FQWL GFTV HIHN NVTK VEME MVLQ KQKC NPAH ADGD CFVF CILT HGRF GAVY SSDE ALIP IREI MSHF TALQ CPRL AEKP KLFF IQAC QGEE IQPS VSIE ADAL NPEQ APTS LQDS IPAE ADFL LGLA TVPG YVSF RHVE EGSW YIQS LCNH LKKL VPRH EDIL SILT AVND DVSR RVDK QGTK KQMP QPAF |
| Gene ID: | 843 |
| Uniprot: | Q92851 |
| Cellular Location: | |
| Calculated MW: | 28kDa/31kDa/51kDa/54kDa/58kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CASP10, ALPS2, FLICE2, MCH4, caspase-10 |
| Background: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CASP10: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.63; Protease Chromosomal Location of Human Ortholog: 2q33-q34 Cellular Component: cytoplasm; plasma membrane; CD95 death-inducing signaling complex; cytosol Molecular Function:protein binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding Biological Process: regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; innate immune response; proteolysis Disease: Lymphoma, Non-hodgkin, Familial; Gastric Cancer; Autoimmune Lymphoproliferative Syndrome, Type Iia |
| NCBI Summary: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q92851 |
| NCBI GenInfo Identifier: | 12644463 |
| NCBI Gene ID: | 843 |
| NCBI Accession: | Q92851.3 |
| UniProt Secondary Accession: | Q92851,Q68HC0, Q6KF62, Q6KF63, Q8IUP5, Q8WYQ8, Q99845 Q9Y2U6, Q9Y2U7, |
| UniProt Related Accession: | Q92851 |
| Molecular Weight: | 521 |
| NCBI Full Name: | Caspase-10 |
| NCBI Synonym Full Names: | caspase 10, apoptosis-related cysteine peptidase |
| NCBI Official Symbol: | CASP10 |
| NCBI Official Synonym Symbols: | MCH4; ALPS2; FLICE2 |
| NCBI Protein Information: | caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2 |
| UniProt Protein Name: | Caspase-10 |
| UniProt Synonym Protein Names: | Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4Cleaved into the following 2 chains:Caspase-10 subunit p23/17; Caspase-10 subunit p12 |
| Protein Family: | Caspase |
| UniProt Gene Name: | CASP10 |
| UniProt Entry Name: | CASPA_HUMAN |
 | Immunofluorescence analysis of HeLa cells using Caspase-10 Polyclonal Antibody (CAB0169) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
Anti-Caspase-2 Antibody (CAB4888)
Cell Death Antibodies 2
OverviewProduct Name:Caspase-2 Rabbit mAbProduct Code:CAB4888Size:20uL, 50uL, 100uLSynonyms:CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57
