Anti-BCL2A1 Antibody (CAB0134)
- SKU:
- CAB0134
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Antibody Name: | Anti-BCL2A1 Antibody (CAB0134) |
| Antibody SKU: | CAB0134 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting, Immunofluorescence |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 70-150 of human BCL2A1 (NP_004040.1). |
| Application: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 70-150 of human BCL2A1 (NP_004040.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | LFNQ VMEK EFED GIIN WGRI VTIF AFEG ILIK KLLR QQIA PDVD TYKE ISYF VAEF IMNN TGEW IRQN GGWE NGFV KKFE P |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 18kDa/20kDa |
| Observed MW: | Refer to figures |
| Synonyms: | BCL2A1, ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1 |
| Background: | This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
 | Immunofluorescence analysis of THP-1 cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of Jurkat cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining. |
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