Anti-BCL2A1 Antibody (CAB0134)

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SKU:
CAB0134
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Description

Antibody Name:Anti-BCL2A1 Antibody (CAB0134)
Antibody SKU:CAB0134
Antibody Size:50µL, 100µL
Application:Western blotting, Immunofluorescence
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 70-150 of human BCL2A1 (NP_004040.1).
Application:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500 - 1:2000
IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 70-150 of human BCL2A1 (NP_004040.1).
Purification Method:Affinity purification
Storage Buffer:Store at 4°C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:LFNQ VMEK EFED GIIN WGRI VTIF AFEG ILIK KLLR QQIA PDVD TYKE ISYF VAEF IMNN TGEW IRQN GGWE NGFV KKFE P
Cellular Location:Cytoplasm
Calculated MW:18kDa/20kDa
Observed MW:Refer to figures
Synonyms:BCL2A1, ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1
Background:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunofluorescence analysis of THP-1 cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining.Immunofluorescence analysis of THP-1 cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Jurkat cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining.Immunofluorescence analysis of Jurkat cells using BCL2A1 Rabbit pAb at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining.
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
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