Cell Cycle Antibodies 2

BCCIP Rabbit Polyclonal Antibody (CAB8586)

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SKU:
CAB8586
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
TOK1, TOK-1, BCCIP
Research Use:
Cell Cycle
Frequently bought together:

Description

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BCCIP Antibody (CAB8586)

The BCCIP Antibody (CAB8586) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.BCCIP, also known as BCC-interacting protein, plays a crucial role in maintaining genomic stability and proper cell division. Dysregulation of BCCIP has been linked to cancer development and progression, making it a promising target for cancer research.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:BCCIP Antibody
SKU:CAB8586
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MASR SKRR AVES GVPQ PPDP PVQR DEEE EKEV ENED EDDD DSDK EKDE EDEV IDEE VNIE FEAY SLSD NDYD GIKK LLQQ LFLK APVN TAEL TDLL IQQN HIGS VIKQ TDVS EDSN DDMD EDEV FGFI SLLN LTER KGTQ CVEQ IQEL VLRF CEKN CEKS MVEQ LDKF LNDT TKPV GLLL SERF INVP PQIA LPMY QQLQ KELA GAHR TNKP CGKC YFYL LISK TFVE AGKN NSKK KPSN KKKA ALMF ANAE EEFF YEKA ILKF NYSV QEES DTCL GGKW SFDD VPMT PLRT VMLI PGDK MNEI MDKL KEYL SV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:100 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:TOK1, TOK-1, BCCIP
Positive Sample:SKOV3, HeLa, Mouse brain, Mouse liver, Mouse small intestine
Cellular Localization:Nucleus.
Calculated MW:36kDa
Observed MW:50kDa

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Purification MethodAffinity purification
Gene ID56647
RRIDAB_2768573
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using BCCIP Rabbit pAb (CAB8586) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human breast using BCCIP Rabbit pAb (CAB8586) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
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