Epigenetics & Nuclear Signaling Antibodies 3

ATRIP Rabbit Polyclonal Antibody (CAB5041)

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SKU:
CAB5041
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATRIP
Research Area:
Epigenetics and Nuclear Signaling
Research Use:
Epigenetics and Nuclear Signaling
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Description

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ATRIP Antibody (CAB5041)

The ATRIP Antibody (CAB5041) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot analyses.ATRIP is crucial for the activation of ATR kinase in response to DNA damage, playing a key role in the maintenance of genomic stability. Dysregulation of the ATR pathway has been linked to various human diseases, including cancer and neurodegenerative disorders.

This antibody is validated for use in WB, IF/ICC, IP, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:ATRIP Antibody
SKU:CAB5041
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MAGT SAPG SKRR SEPP APRP GPPP GTGH PPSK RARG FSAA AAPD PDDP FGAH GDFT ADDL EELD TLAS QALS QCPA AARD VSSD HKVH RLLD GMSK NPSG KNRE TVPI KDNF ELEV LQAQ YKEL KEKM KVME EEVL IKNG EIKI LRDS LHQT ESVL EEQR RSHF LLEQ EKTQ ALSD KEKE FSKK LQSL QSEL QFKD AEMN ELRT KLQT SERA NKLA APSV SHVS PRKN PSVV IKPE ACSP QFGK TSFP TKES FSAN MSLP
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
IP0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:ATRIP
Positive Sample:Jurkat, HeLa
Cellular Localization:Nucleus.
Calculated MW:86kDa
Observed MW:100kDa/113kDa

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID84126
RRIDAB_2765993
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using ATRIP Rabbit pAb (CAB5041) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunoprecipitation analysis of 200 μg extracts of HeLa cells using 1 μg ATRIP antibody (CAB5041). Western blot was performed from the immunoprecipitate using ATRIP antibody (CAB5041) at a dilution of 1:1000.
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