Cell Biology Antibodies 12
Anti-ATAD3A Antibody (CAB8230)
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- SKU:
- CAB8230
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | ATAD3A Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8230 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ATAD3A (NP_001164006.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, MCF7, HepG2, Mouse liver, Mouse kidney, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ATAD3A (NP_001164006.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSWL FGIN KGPK GEGA GPPP PLPP AQPG AEGG GDRG LGDR PAPK DKWS NFDP TGLE RAAK AARE LEHS RYAK DALN LAQM QEQT LQLE QQSK LKEY EAAV EQLK SEQI RAQA EERR KTLS EETR QHQA RAQY QDKL ARQR YEDQ LKQQ QLLN EENL RKQE ESVQ KQEA MRRA TVER EMEL RHKN EMLR VEAE ARAR AKAE RENA DIIR EQIR LKAA EHRQ TVLE SIRT AGTL FGEG FRAF |
| Gene ID: | 55210 |
| Uniprot: | Q9NVI7 |
| Cellular Location: | Mitochondrion inner membrane, Mitochondrion matrix, Single-pass membrane protein, mitochondrion nucleoid |
| Calculated MW: | 57kDa/66kDa/71kDa |
| Observed MW: | 70kDa |
| Synonyms: | ATAD3A, HAYOS, ATPase family |
| Background: |
| UniProt Protein Function: | ATAD3A: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. Belongs to the AAA ATPase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: mitochondrion Biological Process: cell growth; negative regulation of apoptosis |
| NCBI Summary: | ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008] |
| UniProt Code: | Q9NVI7 |
| NCBI GenInfo Identifier: | 84028405 |
| NCBI Gene ID: | 55210 |
| NCBI Accession: | Q9NVI7.2 |
| UniProt Secondary Accession: | Q9NVI7,Q5SV23, Q8N275, Q96A50, B3KPB3, D2K8Q1, G3V1I6 |
| UniProt Related Accession: | Q9NVI7 |
| Molecular Weight: | 57,948 Da |
| NCBI Full Name: | ATPase family AAA domain-containing protein 3A |
| NCBI Synonym Full Names: | ATPase family, AAA domain containing 3A |
| NCBI Official Symbol: | ATAD3A |
| NCBI Protein Information: | ATPase family AAA domain-containing protein 3A |
| UniProt Protein Name: | ATPase family AAA domain-containing protein 3A |
| Protein Family: | ATPase family AAA domain-containing protein |
| UniProt Gene Name: | ATAD3A |
| UniProt Entry Name: | ATD3A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ATAD3A antibody (CAB8230) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human stomach using ATAD3A antibody (CAB8230) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using ATAD3A antibody (CAB8230) at dilution of 1:100 (40x lens). |
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