Cell Biology Antibodies 2
Anti-APOH Antibody (CAB1220)
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- SKU:
- CAB1220
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-APOH Antibody |
| Antibody SKU: | CAB1220 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-345 of human APOH (NP_000033.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 22Rv1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-345 of human APOH (NP_000033.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RTCP KPDD LPFS TVVP LKTF YEPG EEIT YSCK PGYV SRGG MRKF ICPL TGLW PINT LKCT PRVC PFAG ILEN GAVR YTTF EYPN TISF SCNT GFYL NGAD SAKC TEEG KWSP ELPV CAPI ICPP PSIP TFAT LRVY KPSA GNNS LYRD TAVF ECLP QHAM FGND TITC TTHG NWTK LPEC REVK CPFP SRPD NGFV NYPA KPTL YYKD KATF GCHD GYSL DGPE EIEC TKLG NWSA MPSC KASC KVPV KKAT VVYQ GERV KIQE KFKN GMLH GDKV SFFC KNKE KKCS YTED AQCI DGTI EVPK CFKE HSSL AFWK TDAS DVKP C |
| Gene ID: | 350 |
| Uniprot: | P02749 |
| Cellular Location: | Secreted |
| Calculated MW: | 38kDa |
| Observed MW: | 45kDa |
| Synonyms: | APOH, B2G1, B2GP1, BG |
| Background: | Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. |
| UniProt Protein Function: | APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. |
| UniProt Protein Details: | Protein type:Secreted; Lipid-binding; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17q24.2 Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface Molecular Function:heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; triacylglycerol metabolic process; positive regulation of blood coagulation; negative regulation of fibrinolysis; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis |
| NCBI Summary: | Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02749 |
| NCBI GenInfo Identifier: | 543826 |
| NCBI Gene ID: | 350 |
| NCBI Accession: | P02749.3 |
| UniProt Secondary Accession: | P02749,Q9UCN7, B2R9M3, |
| UniProt Related Accession: | P02749 |
| Molecular Weight: | 345 |
| NCBI Full Name: | Beta-2-glycoprotein 1 |
| NCBI Synonym Full Names: | apolipoprotein H (beta-2-glycoprotein I) |
| NCBI Official Symbol: | APOH |
| NCBI Official Synonym Symbols: | BG; B2G1; B2GP1 |
| NCBI Protein Information: | beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein |
| UniProt Protein Name: | Beta-2-glycoprotein 1 |
| UniProt Synonym Protein Names: | APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI |
| Protein Family: | Beta-2-glycoprotein |
| UniProt Gene Name: | APOH |
| UniProt Entry Name: | APOH_HUMAN |
 | Western blot analysis of extracts of 22Rv1 cells, using APOH antibody (CAB1220) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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