Metabolism Antibodies 1
Anti-APOC3 Antibody (CAB1409)
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- SKU:
- CAB1409
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-APOC3 Antibody |
| Antibody SKU: | CAB1409 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-99 of human APOC3 (NP_000031.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HT-29, mouse liver, mouse small intestine, rat small intestine |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-99 of human APOC3 (NP_000031.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQPR VLLV VALL ALLA SARA SEAE DASL LSFM QGYM KHAT KTAK DALS SVQE SQVA QQAR GWVT DGFS SLKD YWST VKDK FSEF WDLD PEVR PTSA VAA |
| Gene ID: | 345 |
| Uniprot: | P02656 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 11kDa |
| Synonyms: | APOC3, APOCIII, HALP2 |
| Background: | Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. |
| UniProt Protein Function: | APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Lipid-binding; Secreted Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: chylomicron; early endosome; extracellular region; extracellular space Molecular Function:cholesterol binding; enzyme regulator activity; lipase inhibitor activity; phospholipid binding Biological Process: cholesterol efflux; cholesterol homeostasis; G-protein coupled receptor protein signaling pathway; lipoprotein metabolic process; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; regulation of Cdc42 protein signal transduction; retinoid metabolic process; reverse cholesterol transport; triacylglycerol catabolic process; triacylglycerol metabolic process Disease: Apolipoprotein C-iii Deficiency |
| NCBI Summary: | Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02656 |
| NCBI GenInfo Identifier: | 114026 |
| NCBI Gene ID: | 345 |
| NCBI Accession: | P02656.1 |
| UniProt Secondary Accession: | P02656,Q08E83, Q6Q786, |
| UniProt Related Accession: | P02656 |
| Molecular Weight: | 10,852 Da |
| NCBI Full Name: | Apolipoprotein C-III |
| NCBI Synonym Full Names: | apolipoprotein C3 |
| NCBI Official Symbol: | APOC3 |
| NCBI Official Synonym Symbols: | HALP2; APOCIII |
| NCBI Protein Information: | apolipoprotein C-III |
| UniProt Protein Name: | Apolipoprotein C-III |
| UniProt Synonym Protein Names: | Apolipoprotein C3 |
| Protein Family: | Apolipoprotein |
| UniProt Gene Name: | APOC3 |
| UniProt Entry Name: | APOC3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using APOC3 antibody (CAB1409) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using APOC3 antibody (CAB1409) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver using APOC3 antibody (CAB1409) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using APOC3 antibody (CAB1409) at dilution of 1:100 (40x lens). |
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