Cell Biology Antibodies 10
Anti-ANXA4 Antibody (CAB6280)
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- SKU:
- CAB6280
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ANXA4 Antibody |
| Antibody SKU: | CAB6280 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 112-321 of human ANXA4 (NP_001144.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, MCF7, A-549, SW620, HepG2, Mouse liver, Mouse kidney, Mouse lung, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 112-321 of human ANXA4 (NP_001144.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IEIL ASRT PEEI RRIS QTYQ QQYG RSLE DDIR SDTS FMFQ RVLV SLSA GGRD EGNY LDDA LVRQ DAQD LYEA GEKK WGTD EVKF LTVL CSRN RNHL LHVF DEYK RISQ KDIE QSIK SETS GSFE DALL AIVK CMRN KSAY FAEK LYKS MKGL GTDD NTLI RVMV SRAE IDML DIRA HFKR LYGK SLYS FIKG DTSG DYRK VLLV LCGG DD |
| Gene ID: | 307 |
| Uniprot: | P09525 |
| Cellular Location: | |
| Calculated MW: | 27kDa/35kDa |
| Observed MW: | 35kDa |
| Synonyms: | ANXA4, ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36 |
| Background: | Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ANXA4: a calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. |
| UniProt Protein Details: | Protein type:Lipid-binding; Calcium-binding Chromosomal Location of Human Ortholog: 2p13 Cellular Component: nuclear membrane; cell surface; perinuclear region of cytoplasm; cytoplasm; plasma membrane; vesicle membrane; nucleus Molecular Function:phospholipase inhibitor activity; identical protein binding; NF-kappaB binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding Biological Process: regulation of transcription from RNA polymerase II promoter; epithelial cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of catalytic activity; signal transduction; negative regulation of apoptosis |
| NCBI Summary: | Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09525 |
| NCBI GenInfo Identifier: | 1703319 |
| NCBI Gene ID: | 307 |
| NCBI Accession: | P09525.4 |
| UniProt Secondary Accession: | P09525,Q96F33, Q9BWK1, |
| UniProt Related Accession: | P09525 |
| Molecular Weight: | 35,883 Da |
| NCBI Full Name: | Annexin A4 |
| NCBI Synonym Full Names: | annexin A4 |
| NCBI Official Symbol: | ANXA4 |
| NCBI Official Synonym Symbols: | ANX4; PIG28; ZAP36; HEL-S-274 |
| NCBI Protein Information: | annexin A4; P32.5; PP4-X; PAP-II; annexin-4; protein II; endonexin I; lipocortin IV; chromobindin-4; 35-beta calcimedin; proliferation-inducing gene 28; proliferation-inducing protein 28; placental anticoagulant protein II; epididymis secretory protein Li 274; carbohydrate-binding protein p33/p41; annexin IV (placental anticoagulant protein II) |
| UniProt Protein Name: | Annexin A4 |
| UniProt Synonym Protein Names: | 35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PP4-X; Placental anticoagulant protein II; PAP-II; Protein II |
| Protein Family: | Annexin |
| UniProt Gene Name: | ANXA4 |
| UniProt Entry Name: | ANXA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANXA4 antibody (CAB6280) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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