Epigenetics & Nuclear Signaling Antibodies 3

Androgen Receptor Rabbit Polyclonal Antibody (CAB2053)

(No reviews yet) Write a Review
SKU:
CAB2053
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
KD, AIS, AR8, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA, Androgen Receptor
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Androgen Receptor Antibody (CAB2053)

The Androgen Receptor Antibody (CAB2053) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using rabbits, specifically targets the androgen receptor protein in human samples, making it ideal for use in Western blot applications.The androgen receptor plays a key role in mediating the effects of androgens, a class of hormones responsible for male characteristics and functions. Dysregulation of the androgen receptor has been implicated in various diseases, including prostate cancer and androgen insensitivity syndrome.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Androgen Receptor Antibody
SKU:CAB2053
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MEVQ LGLG RVYP RPPS KTYR GAFQ NLFQ SVRE VIQN PGPR HPEA ASAA PPGA SLLL LQQQ QQQQ QQQQ QQQQ QQQQ QQQQ ETSP RQQQ QQQG EDGS PQAH
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:KD, AIS, AR8, TFM, DHTR, SBMA, HYSP1, NR3C4, SMAX1, HUMARA, Androgen Receptor
Positive Sample:Mouse testis, Rat testis
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:99kDa
Observed MW:80kDa/110kDa

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID367
RRIDAB_2764076
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Rat testis, using Androgen Receptor Rabbit pAb (CAB2053) at 1:600 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3s.
Product ImageWestern blot analysis of lysates from Mouse testis, using Androgen Receptor Rabbit pAb (CAB2053) at 1:600 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
View AllClose

0 Reviews

View AllClose

Related Products