Cell Biology Antibodies 4

AGTR1 Rabbit Polyclonal Antibody (CAB14201)

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SKU:
CAB14201
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
AT1, AG2S, AT1B, AT1R, ATR1, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B, AT1R/AGTR1
Research Use:
Cell Biology
Frequently bought together:

Description

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AGTR1 Antibody (CAB14201)

The AGTR1 Antibody (CAB14201) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human AGTR1 and has been validated for use in Western blotting applications.AGTR1 is a G-protein-coupled receptor that mediates the effects of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. Dysregulation of AGTR1 signaling has been implicated in cardiovascular diseases such as hypertension and heart failure, making it a promising target for drug development.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:AGTR1 Antibody
SKU:CAB14201
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LIQL GIIR DCRI ADIV DTAM PITI CIAY FNNC LNPL FYGF LGKK FKRY FLQL LKYI PPKA KSHS NLST KMST LSYR PSDN VSSS TKKP APCF EVE
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:AT1, AG2S, AT1B, AT1R, ATR1, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B, AT1R/AGTR1
Positive Sample:HepG2, U-87MG, C2C12, PC-12
Cellular Localization:Cell Membrane, Multi-Pass Membrane Protein.
Calculated MW:41kDa
Observed MW:62kDa

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID185
RRIDAB_2761061
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using AT1R/AGTR1 Rabbit pAb (CAB14201) at 1:1500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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