Cell Biology Antibodies 10

AGR2 Rabbit Polyclonal Antibody (CAB7064)

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SKU:
CAB7064
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
AG2, AG-2, HPC8, GOB-4, HAG-2, RIFTD, XAG-2, PDIA17, HEL-S-116, AGR2
Research Use:
Cell Biology
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Description

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AGR2 Antibody (CAB7064)

The AGR2 Antibody (CAB7064) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By targeting the AGR2 protein, this antibody enables precise detection and analysis in a variety of cell types, providing insights into the role of AGR2 in cancer biology.AGR2, a member of the protein disulfide isomerase family, is overexpressed in many types of cancer and is believed to promote tumor growth, invasion, and resistance to therapy.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:AGR2 Antibody
SKU:CAB7064
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:RDTT VKPG AKKD TKDS RPKL PQTL SRGW GDQL IWTQ TYEE ALYK SKTS NKPL MIIH HLDE CPHS QALK KVFA ENKE IQKL AEQF VLLN LVYE TTDK HLSP DGQY VPRI MFVD PSLT VRAD ITGR YSNR LYAY EPAD TALL LDNM KKAL KLLK TEL
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:AG2, AG-2, HPC8, GOB-4, HAG-2, RIFTD, XAG-2, PDIA17, HEL-S-116, AGR2
Positive Sample:HT-29, BT-474, MCF7, NCI-H460, Mouse stomach, Mouse liver, Mouse small intestine, Rat lung
Cellular Localization:Endoplasmic Reticulum, Secreted.
Calculated MW:20kDa
Observed MW:20kDa

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.

Purification MethodAffinity purification
Gene ID10551
RRIDAB_2767619
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using AGR2 Rabbit pAb (CAB7064) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human lung cancer using AGR2 Rabbit pAb (CAB7064) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunofluorescence analysis of L929 cells using AGR2 Rabbit pAb (CAB7064) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of U-2 OS cells using AGR2 Rabbit pAb (CAB7064) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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