ACVR1 Rabbit Monoclonal Antibody (CAB19274)

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SKU:
CAB19274
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, ACVR1
Research Use:
Cell Biology
Frequently bought together:

Description

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ACVR1 Monoclonal Antibody (CAB19274)

The ACVR1 Monoclonal Antibody (CAB19274) is a high-quality antibody developed for reliable detection and analysis of target proteins. The antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in a variety of research applications.ACVR1, also known as activin receptor type-1, plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, development, and immune responses. Dysregulation of ACVR1 has been implicated in various diseases, including cancer and developmental disorders.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:ACVR1 Monoclonal Antibody
SKU:CAB19274
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC2449
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:VLWE VARR MVSN GIVE DYKP PFYD VVPN DPSF EDMR KVVC VDQQ RPNI PNRW FSDP TLTS LAKL MKEC WYQN PSAR LTAL RIKK TLTK IDNS LDKL KTDC
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, ACVR1
Positive Sample:293T, A549, MCF7, Mouse brain, Rat testis, Rat brain
Cellular Localization:Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:57kDa
Observed MW:57kDa

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Purification MethodAffinity purification
Gene ID90
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Mouse brain, using ACVR1 Rabbit mAb (CAB19274) at1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageWestern blot analysis of various lysates using ACVR1 Rabbit mAb (CAB19274) at1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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