WDR34 Antibody (PACO38970)
- SKU:
- PACO38970
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDR34 Antibody (PACO38970) |
| Antibody SKU: | PACO38970 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human WD repeat-containing protein 34 protein (1-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: WDR34 antibody at 1.5µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: MDA-MB-231 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 58 kDa. Observed band size: 58 kDa. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO38970 at dilution of 1:100. |
| Background: | Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 β stimulation. |
| Synonyms: | WD repeat-containing protein 34, WDR34 |
| UniProt Protein Function: | WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.Chromosomal Location of Human Ortholog: 9q34.11Cellular Component: axoneme; centriole; cytoplasmMolecular Function: protein bindingDisease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q96EX3 |
| NCBI GenInfo Identifier: | 88985038 |
| NCBI Gene ID: | 89891 |
| NCBI Accession: | Q96EX3.2 |
| UniProt Secondary Accession: | Q96EX3,Q5VXV4, Q9BV46 |
| UniProt Related Accession: | Q96EX3 |
| Molecular Weight: | 57,801 Da |
| NCBI Full Name: | WD repeat-containing protein 34 |
| NCBI Synonym Full Names: | WD repeat domain 34 |
| NCBI Official Symbol: | WDR34 |
| NCBI Official Synonym Symbols: | DIC5; FAP133; SRTD11; bA216B9.3 |
| NCBI Protein Information: | WD repeat-containing protein 34 |
| UniProt Protein Name: | WD repeat-containing protein 34 |
| UniProt Synonym Protein Names: | |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR34 |
| UniProt Entry Name: | WDR34_HUMAN |
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