Von Hippel Lindau/VHL Monoclonal Antibody (CAB23239)

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SKU:
CAB23239
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Von Hippel Lindau/VHL Monoclonal Antibody
Product Code:CAB23239
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC59984
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, 293T, Mouse brain, Mouse kidney, Rat brain, Rat kidney
Cellular Location:Cytoplasm, Membrane, Nucleus, Nucleus, Peripheral membrane protein

This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma.

Immunogen:Recombinant protein of human Von Hippel Lindau/VHL.
Sequence:Email for sequence
Synonyms:RCA1, VHL1, pVHL, HRCA1
Calculated MW:24kDa
Observed MW:18-24kDa
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