Name: VKORC1 Antibody (PACO59013)
SKU: PACO59013
Availability: OutOfStock

Antibody Name:	VKORC1 Antibody (PACO59013)
Antibody SKU:	PACO59013
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:	Human
Immunogen:	Recombinant Human Vitamin K epoxide reductase complex subunit 1 protein (30-74AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

IHC image of PACO59013 diluted at 1:200 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of PACO59013 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Synonyms:	Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1), VKORC1, VKOR

UniProt Protein Function:	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
NCBI Summary:	This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
UniProt Code:	Q9BQB6
NCBI GenInfo Identifier:	62511226
NCBI Gene ID:	79001
NCBI Accession:	Q9BQB6.1
UniProt Secondary Accession:	Q9BQB6,Q6UX90, Q7Z2R4, A6NIQ6, B2R4Z6,
UniProt Related Accession:	Q9BQB6
Molecular Weight:	9,875 Da
NCBI Full Name:	Vitamin K epoxide reductase complex subunit 1
NCBI Synonym Full Names:	vitamin K epoxide reductase complex subunit 1
NCBI Official Symbol:	VKORC1
NCBI Official Synonym Symbols:	VKOR; MST134; MST576; VKCFD2; EDTP308
NCBI Protein Information:	vitamin K epoxide reductase complex subunit 1
UniProt Protein Name:	Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names:	Vitamin K1 2,3-epoxide reductase subunit 1
Protein Family:	Vitamin K epoxide reductase complex
UniProt Gene Name:	VKORC1