VDR Monoclonal Antibody (CAB23289)
- SKU:
- CAB23289
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | VDR Monoclonal Antibody |
| Product Code: | CAB23289 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60266 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF 1:50-1:200, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | T-47D, HeLa, NIH/3T3, Jurkat |
| Cellular Location: | Nucleus, Cytoplasm, Cytosol |
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VDR(NP_000367.1). |
| Sequence: | MEAMA ASTSL PDPGD FDRNV PRICG VCGDR ATGFH FNAMT CEGCK GFFRR SMKRK ALFTC PFNGD CRITK DNRRH CQACR LKRCV DIGMM KEFIL TDEEV |
| Synonyms: | NR1I1, PPP1R163 |
| Calculated MW: | 48kDa |
| Observed MW: | 48kDa/54kDa |
Related Products
Anti-VDR Antibody (CAB20840)
