Name: TTBK2 Antibody (PACO20784)
SKU: PACO20784
Availability: OutOfStock

Antibody Name:	TTBK2 Antibody (PACO20784)
Antibody SKU:	PACO20784
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human TTBK2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20784(TTBK2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20784(TTBK2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Synonyms:	tau tubulin kinase 2

UniProt Protein Function:	TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; Kinase, protein; CK1 group; TTBK family Chromosomal Location of Human Ortholog: 15q15.2 Cellular Component: centriole; extracellular space; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; ATP binding Biological Process: regulation of cell shape; smoothened signaling pathway; peptidyl-serine phosphorylation; organelle organization and biogenesis; cilium biogenesis Disease: Spinocerebellar Ataxia 11
NCBI Summary:	This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
UniProt Code:	Q6IQ55
NCBI GenInfo Identifier:	116242833
NCBI Gene ID:	146057
NCBI Accession:	Q6IQ55.2
UniProt Secondary Accession:	Q6IQ55,O94932, Q6ZN52, Q8IVV1,
UniProt Related Accession:	Q6IQ55
Molecular Weight:	1244
NCBI Full Name:	Tau-tubulin kinase 2
NCBI Synonym Full Names:	tau tubulin kinase 2
NCBI Official Symbol:	TTBK2
NCBI Official Synonym Symbols:	TTBK; SCA11
NCBI Protein Information:	tau-tubulin kinase 2
UniProt Protein Name:	Tau-tubulin kinase 2
Protein Family:	Tau-tubulin kinase
UniProt Gene Name:	TTBK2
UniProt Entry Name:	TTBK2_HUMAN