Description
Product Name: | TRPM6 Polyclonal Antibody |
Product Code: | CAB10704 |
Reactivity: | Human |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:2000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Cellular Location: | Cell membrane, Multi-pass membrane protein |
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 740-840 of human TRPM6 (NP_060132.3). |
Sequence: | RKNSW LKIII SIILP PTILT LEFKS KAEMS HVPQS QDFQF MWYYS DQNAS SSKES ASVKE YDLER GHDEK LDENQ HFGLE SGHQH LPWTR KVYEF YSAPI V |
Synonyms: | HSH, HMGX, HOMG, CHAK2, HOMG1 |
Calculated MW: | 232kDa |
Observed MW: | Refer to figures |