TNFR2/TNFRSF1B Monoclonal Antibody
- SKU:
- CAB23192
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | TNFR2/TNFRSF1B Monoclonal Antibody |
| Product Code: | CAB23192 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57371 |
| Reactivity: | Human |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Secreted |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
| Immunogen: | Recombinant protein of human TNFR2/TNFRSF1B. |
| Sequence: | Email for sequence |
| Synonyms: | p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II |
| Calculated MW: | 48kDa |
| Observed MW: | Refer to figures |
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