Description
Antibody Name: | TMC8 Antibody |
Antibody SKU: | PACO02507 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the C-terminal region of human TMC8. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | TMC8; EVER2; EVIN2; Transmembrane channel-like protein 8; Epidermodysplasia verruciformis protein 2 |
UniProt Protein Function: | TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 17q25.3Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; Golgi apparatus; nuclear membraneMolecular Function: protein binding; receptor bindingBiological Process: negative regulation of protein binding; negative regulation of protein oligomerization; regulation of cell growth; zinc ion homeostasisDisease: Epidermodysplasia Verruciformis |
UniProt Protein Details: | |
NCBI Summary: | Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8IU68 |
NCBI GenInfo Identifier: | 74714272 |
NCBI Gene ID: | 147138 |
NCBI Accession: | Q8IU68.1 |
UniProt Secondary Accession: | Q8IU68,Q2YDC0, Q8IWU7, Q8N358, Q8NF04 |
UniProt Related Accession: | Q8IU68 |
Molecular Weight: | 56,132 Da |
NCBI Full Name: | Transmembrane channel-like protein 8 |
NCBI Synonym Full Names: | transmembrane channel like 8 |
NCBI Official Symbol: | TMC8 |
NCBI Official Synonym Symbols: | EV2; EVER2; EVIN2 |
NCBI Protein Information: | transmembrane channel-like protein 8 |
UniProt Protein Name: | Transmembrane channel-like protein 8 |
UniProt Synonym Protein Names: | Epidermodysplasia verruciformis protein 2 |
Protein Family: | Transmembrane channel-like protein |
UniProt Gene Name: | TMC8 |
UniProt Entry Name: | TMC8_HUMAN |