Thpo Antibody (PACO32440)
- SKU:
- PACO32440
- Product Type:
- Antibody
- Reactivity:
- Rat
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Thpo Antibody (PACO32440) |
| Antibody SKU: | PACO32440 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Mouse, Human |
| Immunogen: | Recombinant Rat Thrombopoietin protein (22-194AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Thpo antibody at 4µg/ml Lane 1: Mouse liver tissue Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa . |
| Background: | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Synonyms: | Thrombopoietin, Thpo |
| UniProt Protein Function: | THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:hormone activity; cytokine activity; receptor binding Biological Process: cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of cell proliferation; response to lipopolysaccharide; myeloid cell differentiation; positive regulation of megakaryocyte differentiation; positive regulation of protein amino acid phosphorylation |
| UniProt Code: | P49745 |
| NCBI GenInfo Identifier: | 1730007 |
| NCBI Gene ID: | 103690065 |
| NCBI Accession: | P49745.1 |
| Molecular Weight: | 34,556 Da |
| NCBI Full Name: | Thrombopoietin |
| NCBI Synonym Full Names: | thrombopoietin |
| NCBI Official Symbol: | LOC103690065 |
| NCBI Protein Information: | thrombopoietin |
| UniProt Protein Name: | Thrombopoietin |
| Protein Family: | Thyroid peroxidase |
| UniProt Gene Name: | Thpo |
| UniProt Entry Name: | TPO_RAT |
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