Antibody Name:	TFAP2E Antibody (PACO60172)
Antibody SKU:	PACO60172
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:	Human
Immunogen:	Recombinant Human Transcription factor AP-2-epsilon protein (66-175AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: TFAP2E antibody at 3.63µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.

Background:

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP α and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).

Synonyms:

Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon), TFAP2E

UniProt Protein Function:	AP-2 epsilon: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation. Belongs to the AP-2 family.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 1p34.3Cellular Component: nucleusMolecular Function: protein homodimerization activity; protein heterodimerization activityBiological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; anatomical structure development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q6VUC0
NCBI GenInfo Identifier:	194353976
NCBI Gene ID:	339488
NCBI Accession:	NP_848643.2
UniProt Secondary Accession:	Q6VUC0,Q8IW12
UniProt Related Accession:	Q6VUC0
Molecular Weight:	46,212 Da
NCBI Full Name:	transcription factor AP-2-epsilon
NCBI Synonym Full Names:	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
NCBI Official Symbol:	TFAP2E
NCBI Official Synonym Symbols:	AP2E
NCBI Protein Information:	transcription factor AP-2-epsilon; AP2-epsilon; activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit
UniProt Protein Name:	Transcription factor AP-2-epsilon
UniProt Synonym Protein Names:	Activating enhancer-binding protein 2-epsilon
Protein Family:	Transcription factor
UniProt Gene Name:	TFAP2E
UniProt Entry Name:	AP2E_HUMAN