Tamm Horsfall Glycoprotein Polyclonal Antibody
- SKU:
- CAB22544
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Tamm Horsfall Glycoprotein Polyclonal Antibody |
| Product Code: | CAB22544 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:100-1:500, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse kidney |
| Cellular Location: | apical plasma membrane, basolateral plasma membrane, cell surface, ciliary membrane, cilium, endoplasmic reticulum, extracellular exosome, extracellular space, Golgi lumen, spindle pole |
The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-324 of human Tamm Horsfall Glycoprotein. (NP_003352.2). |
| Sequence: | LRGWY RFVGQ GGARM AETCV PVLRC NTAAP MWLNG THPSS DEGIV SRKAC AHWSG HCCLW DASVQ VKACA GGYYV YNLTA PPECH LAYCT DPSSV EGTCE ECSID EDCKS NNGRW HCQCK QDFNI TDISL LEHRL ECGAN DMKVS LGKCQ |
| Synonyms: | THP, FJHN, HNFJ, THGP, HNFJ1, MCKD2, ADTKD1, ADMCKD2 |
| Calculated MW: | 70kDa |
| Observed MW: | 105-120kDa |
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