STAT3 Monoclonal Antibody
- SKU:
- CAB22434
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | STAT3 Monoclonal Antibody |
| Product Code: | CAB22434 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC2576 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200, IP 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Rat brain |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human STAT3 (P40763). |
| Sequence: | MAQWN QLQQL DTRYL EQLHQ LYSDS FPMEL RQFLA PWIES QDWAY AASKE SHATL VFHNL LGEID QQYSR FLQES NVLYQ HNLRR IKQFL QSRYL EKPME |
| Synonyms: | APRF, HIES, ADMIO, ADMIO1 |
| Calculated MW: | 88kDa |
| Observed MW: | 86kDa |
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[KO/KD Validated] STAT3 Monoclonal Antibody
