SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0654)
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- SKU:
- RPES0654
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
SPHK1/Sphingosine Kinase 1 Recombinant Protein
SPHK1; also known as sphingosine Kinase 1; catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation; survival; migration; cytoskeletal organization; and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory; antiapoptotic; and immune processes.
| Product Name: | SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0654) |
| Product Code: | RPES0654 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | SPHK,SPHK1,SPK |
| Accession: | Q9NYA1-1 |
| Sequence: | Met 1-Leu 384 |
| Fusion tag: | N-His & GST |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was expressed the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 70.3 kDa |
| AP Mol Mass: | 64 kDa |
| Formulation: | Supplied as sterile 20mM Tris; 500mM NaCl; 3mM DTT; 10% glycerol; pH 8.0 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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