SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0654)

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SKU:
RPES0654
Product Type:
Recombinant Protein
Species:
Human

Description

system_update_altDatasheet

SPHK1/Sphingosine Kinase 1 Recombinant Protein

SPHK1; also known as sphingosine Kinase 1; catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation; survival; migration; cytoskeletal organization; and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory; antiapoptotic; and immune processes.

Product Name:SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0654)
Product Code:RPES0654
Size:20µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:SPHK,SPHK1,SPK
Accession:Q9NYA1-1
Sequence:Met 1-Leu 384
Fusion tag:N-His & GST
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was expressed the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:70.3 kDa
AP Mol Mass:64 kDa
Formulation:Supplied as sterile 20mM Tris; 500mM NaCl; 3mM DTT; 10% glycerol; pH 8.0
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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