SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0635)
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- SKU:
- RPES0635
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
SPHK1/Sphingosine Kinase 1 Recombinant Protein
SPHK1; also known as sphingosine Kinase 1; catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P's diverse range of biological activities include cell proliferation, survival, movement, cytoskeletal organization, and development. It is a cell membrane G protein-coupled receptor ligand. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. TNF-alpha signaling and the NF-kappa-B activation pathway, which is involved in inflammatory; antiapoptotic; and immune processes, are both reliant on TSPHK1. SPHK1/Sphingosine Kinase 1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0635) |
| Product Code: | RPES0635 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | SPHK,SPHK1,SPK |
| Accession: | Q9NYA1-1 |
| Sequence: | Met 1-Leu 384 |
| Fusion tag: | |
| Activity: | The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was fused with two additional amino acids (Gly & Pro) at the N-terminus. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 42.7 kDa |
| AP Mol Mass: | 46 kDa |
| Formulation: | Supplied as sterile 20mM Tris; 500mM NaCl; 10% glycerol; pH 8.0 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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