Description
Antibody Name: | Sod1 Antibody (PACO30072) |
Antibody SKU: | PACO30072 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Mouse |
Immunogen: | Recombinant Mouse Superoxide dismutase [Cu-Zn] protein (2-154AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
Synonyms: | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1), Sod1 |
UniProt Protein Function: | SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. |
UniProt Protein Details: | Protein type:EC 1.15.1.1; Apoptosis; Nuclear receptor co-regulator; Oxidoreductase; Mitochondrial Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; extracellular matrix; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrion; myelin sheath; neuron projection; nucleoplasm; nucleus; peroxisome; plasma membrane; protein complex; secretory granule Molecular Function:antioxidant activity; chaperone binding; copper ion binding; enzyme binding; identical protein binding; metal ion binding; oxidoreductase activity; protein binding; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding Biological Process: activation of MAPK activity; aging; anterograde axon cargo transport; auditory receptor cell stereocilium organization and biogenesis; cell aging; cellular iron ion homeostasis; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle maintenance; myelin maintenance in the peripheral nervous system; myeloid cell homeostasis; negative regulation of apoptosis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptosis; neurofilament cytoskeleton organization and biogenesis; ovarian follicle development; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of superoxide release; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of protein kinase activity; relaxation of vascular smooth muscle; removal of superoxide radicals; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; retinal homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide metabolic process; superoxide release; transmission of nerve impulse |
UniProt Code: | P08228 |
NCBI GenInfo Identifier: | 45597447 |
NCBI Gene ID: | 20655 |
NCBI Accession: | NP_035564.1 |
UniProt Related Accession: | P08228 |
Molecular Weight: | 17.8 kDa |
NCBI Full Name: | superoxide dismutase |
NCBI Synonym Full Names: | superoxide dismutase 1, soluble |
NCBI Official Symbol: | Sod1 |
NCBI Official Synonym Symbols: | Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik |
NCBI Protein Information: | superoxide dismutase [Cu-Zn] |
UniProt Protein Name: | Superoxide dismutase [Cu-Zn] |
Protein Family: | Superoxide dismutase |
UniProt Gene Name: | Sod1 |
UniProt Entry Name: | SODC_MOUSE |