SMMHC/MYH11 Monoclonal Antibody
- SKU:
- CAB22339
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | SMMHC/MYH11 Monoclonal Antibody |
| Product Code: | CAB22339 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51916 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A375, Mouse lung, Mouse uterus, Mouse bone(Low expression control), Rat lung |
| Cellular Location: | Melanosome |
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1313 of human SMMHC/MYH11 (NP_002465.1). |
| Sequence: | DSTAT QQELR AKREQ EVTVL KKALD EETRS HEAQV QEMRQ KHAQA VEELT EQLEQ FKRAK ANLDK NKQTL EKENA DLAGE LRVLG QAKQE VEHKK KKLEA QVQEL QSKCS DGERA RAELN DKVHK LQNEV ESVTG MLNEA EGKAI KLAKD VASL |
| Synonyms: | AAT4, FAA4, SMHC, SMMHC, VSCM2, SMMS-1 |
| Calculated MW: | 227kDa |
| Observed MW: | 251kDa |
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