Description
Antibody Name: | SHC2 Antibody |
Antibody SKU: | PACO03787 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Rat |
Immunogen: | synthesized peptide derived from the Internal region of human Sck. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2 |
UniProt Protein Function: | SHC2: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membrane; cytosolMolecular Function: protein binding; receptor tyrosine kinase binding; protein kinase bindingBiological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; Ras protein signal transduction; insulin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P98077 |
NCBI GenInfo Identifier: | 169790811 |
NCBI Gene ID: | 25759 |
NCBI Accession: | NP_036567.2 |
UniProt Secondary Accession: | P98077 |
UniProt Related Accession: | P98077 |
Molecular Weight: | |
NCBI Full Name: | SHC-transforming protein 2 |
NCBI Synonym Full Names: | SHC adaptor protein 2 |
NCBI Official Symbol: | SHC2 |
NCBI Official Synonym Symbols: | SCK; SLI; SHCB |
NCBI Protein Information: | SHC-transforming protein 2 |
UniProt Protein Name: | SHC-transforming protein 2 |
UniProt Synonym Protein Names: | Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2 |
Protein Family: | |
UniProt Gene Name: | SHC2 |
UniProt Entry Name: | SHC2_HUMAN |