SARS-CoV-2 Papain-like Protease Recombinant Protein (RPES0051)

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SKU:
RPES0051
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
Application Area:
Research Tool Proteins
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Description

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SARS-Cov-2 Papain-like Protease Protein (His Tag) (RPES0051)

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

Product Name:SARS-Cov-2 Papain-like Protease Protein (His Tag)
SKU:RPES0051
Size:100µg, 1mg
Species:virus
Synonyms:Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
Tag:N-6His
Sequence:Glu1564-Val1880
Expression Host:E.coli
Accession:YP_009725299.1
Purity:> 90 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Bio-Activity:Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC).The Specific Activity is >80pmols/min/ug
Formulation:Lyophilized from sterile 20mM Tris 500mM NaCl, pH 7.4.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
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