Name: Recombinant Human IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-6His)
SKU: RPES6398
Availability: OutOfStock

Recombinant Human IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-6His)

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SKU:

RPES6398

Product Type:

Recombinant Protein

Species:

Human

Description

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OverviewProduct Name:Recombinant Cynomolgus IL-3 Receptor Subunit Alpha/IL-3RA/CD123 (C-Fc)Product Code:RPES6794Size:10µgSpecies:

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OverviewProduct Name:Recombinant Mouse IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-6His)Product Code:RPES6665Size:10µgSpecies:Mo

Mol Mass:	33.9 kDa
AP Mol Mass:	40-60 kDa
Tag:	C-6His
Purity:	> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:	< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:	Testing in progress

Sequence:	Thr19-Arg305
Accession:	P26951
Storage:	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:	Please refer to the printed manual for detailed information.
Background:	CD123, also known as Interleukin-3 receptor subunit alpha, belongs to the type I cytokine receptor family. In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage‑committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex.