Recombinant Human Fas Ligand / TNFSF6 (N-6His) (RPES6237)

Name: Recombinant Human Fas Ligand / TNFSF6 (N-6His) (RPES6237)
SKU: RPES6237
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Product Name:	Recombinant Human Fas Ligand / TNFSF6 (N-6His)
Product Code:	RPES6237
Size:	10µg
Species:	Human
Expression Host:	HEK293 Cells
Synonyms:	apoptosis (APO-1) antigen ligand 1, Apoptosis antigen ligand, APT1LG1CD95L, APTL, CD178 antigen, CD178, CD95L, CD95-L, Fas antigen ligand, Fas ligand (TNF superfamily, member 6), Fas Ligand, FASLCD95 ligand, FASLG, TNFSF6

Mol Mass:	17.7 kDa
AP Mol Mass:	20-30 kDa
Tag:	N-6His
Purity:	> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:	< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:	Testing in progress

Sequence:	Pro134-Leu281
Accession:	P48023
Storage:	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:	Please refer to the printed manual for detailed information.
Background:	Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.