Rat RBP4 Recombinant Protein (RPES1539)
- SKU:
- RPES1539
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
Rat RBP4 Recombinant Protein
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).
| Product Name: | Rat RBP4 Recombinant Protein (RPES1539) |
| Product Code: | RPES1539 |
| Size: | 20µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | RBPA,Rbp4 |
| Accession: | NP_037294.1 |
| Sequence: | Met 1-Leu 201 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to bind alltrans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.The 50% binding concentration (BC50) is >0.5 µM. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method |
| Protein Construction: | A DNA sequence encoding the extracellular domain of rat RBP4 (NP_037294.1) (Met 1-Leu 201) was expressed, fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 97 % as determined by SDS-PAGE |
| Mol Mass: | 22.8 kDa |
| AP Mol Mass: | 24 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Human RBP4 Recombinant Protein (RPES3926)
Mouse RBP4 Recombinant Protein (RPPB0938)
Growth Factors & Cytokines Recombinant Proteins
Human RBP4 Recombinant Protein (RPPB0937)
Growth Factors & Cytokines Recombinant Proteins
