Rat RAB7A/Rab-7a Recombinant Protein (RPES3277)

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SKU:
RPES3277
Product Type:
Recombinant Protein
Species:
Rat

Description

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Rat RAB7A/Rab-7a Recombinant Protein

RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. In addition, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.

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