Rat IL-22R/IL22RA1 Recombinant Protein (RPES3435)
- SKU:
- RPES3435
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
Rat IL-22R/IL22RA1 Recombinant Protein
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
| Product Name: | Rat IL-22R/IL22RA1 Recombinant Protein (RPES3435) |
| Product Code: | RPES3435 |
| Size: | 50µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | IL-22R, IL22RA1 |
| Accession: | NP_001178798.1 |
| Sequence: | Met1-Ala228 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the rat Il22ra1 (NP_001178798.1) (Met1-Ala228) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 50.8 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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