Cytokines Recombinant Proteins

Rat IL 21 Recombinant Protein (RPPB0635)

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SKU:
RPPB0635
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
A3QPB9
Research Area:
Cytokines

Description

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Product Name:Rat IL 21 Recombinant Protein
Product Code:RPPB0635
Size:10µg
Species:Rat
Target:IL 21
Synonyms:Interleukin-21, IL-21, Il21.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Rat�IL-21 was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized�Rat IL21 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized�Rat IL-21 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution�Rat IL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS
Biological Activity:The biological activity is measured by its ability to proliferate activated B cells.

IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (�C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Interleukin-21�Rat Recombinant produced in E.Coli is a single, non-glycosilated polypeptide chain containing 129 amino acids and having a total molecular mass of 15.2kDa. The�Rat IL-21 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation
UniProt Code:A3QPB9
NCBI GenInfo Identifier:157817103
NCBI Gene ID:365769
NCBI Accession:NP_001102413.1
UniProt Related Accession:A3QPB9
Molecular Weight:17,065 Da
NCBI Full Name:interleukin-21
NCBI Synonym Full Names:interleukin 21
NCBI Official Symbol:Il21��
NCBI Official Synonym Symbols:IL-21��
NCBI Protein Information:interleukin-21
UniProt Protein Name:Interleukin-21
Protein Family:Interleukin
UniProt Gene Name:Il21��
UniProt Entry Name:IL21_RAT
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