Immunoglobulin G (IgG) is a type of antibody composed of four peptide chainstwo identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers.There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum. The IgG2a isotype was able to interact very efficiently with FcgammaR, and share approximately 64-78% amino acid sequence identity with IgG1 and IgG2b in the heavy chain constant region domains, CH1, CH2 and CH3, which cause the diffrence in the interaction with complement, NK and mast cells, induction or inhibition by specific cytokines, and ability to cross the placenta.
Product Name:
Rat IgG2A Fc/Igg-2a Recombinant Protein (RPES0417)
Product Code:
RPES0417
Size:
10µg
Species:
Rat
Expressed Host:
Human cells
Synonyms:
Ig gamma-2A chain C region, Igg-2a
Accession:
P20760
Sequence:
Val98-Lys322
Endotoxin:
<1.0 EU per µg as determined by LAL test.
Protein Construction:
Recombinant Rat Immunoglobulin G2A Fc is produced by our Mammalian expression system and the target gene encoding Val98-Lys322 is expressed.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
35.2 kDa
AP Mol Mass:
30-35 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris, pH 8.5.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetMouse IgG2a-Fc Recombinant Protein As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass thr