Rat CD80/B7 Recombinant Protein (RPES0474)
- SKU:
- RPES0474
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
system_update_altDatasheet
Rat CD80/B7 Recombinant Protein
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
| Product Name: | Rat CD80/B7 Recombinant Protein (RPES0474) |
| Product Code: | RPES0474 |
| Size: | 10µg |
| Species: | Rat |
| Expressed Host: | Human cells |
| Synonyms: | T-lymphocyte activation antigen CD80, Activation B7-1 antigen, B7, CD80 |
| Accession: | O35187 |
| Sequence: | Vla30-Gln248 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by LAL test. |
| Protein Construction: | Recombinant Rat T-lymphocyte Activation Antigen CD81 is produced by our Mammalian expression system and the target gene encoding Vla30-Gln248 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 25.7 kDa |
| AP Mol Mass: | 38 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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