PTPN2 Polyclonal Antibody
- SKU:
- CAB21812
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | PTPN2 Polyclonal Antibody |
| Product Code: | CAB21812 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum, Endoplasmic reticulum-Golgi intermediate compartment, Nucleus |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PTPN2 (NP_536348.1). |
| Sequence: | MPTTI EREFE ELDTQ RRWQP LYLEI RNESH DYPHR VAKFP ENRNR NRYRD VSPYD HSRVK LQNAE NDYIN ASLVD IEEAQ RSYIL TQGPL PNTCC HFWLM VWQQK TKAVV MLNRI VEKES VKCAQ YWPTD DQEML FKETG FSVKL LSEDV KSYYT VHLLQ LENIN SGETR TISHF HYTTW PDFGV PESPA SFLNF LFKVR ESGSL NPDHG PAVIH CSAGI GRSGT FSLVD TCLVL MEKGD DINIK QVLLN MRKYR MGLIQ TPDQL RFSYM AIIEG AKCIK GDSSI QKRWK ELSKE DLSPA FDHSP NKIMT EKYNG NRIGL EEEKL TGDRC TGLSS KMQDT MEENS ERPRL TDT |
| Synonyms: | PTN2, PTPT, TCPTP, TC-PTP, TCELLPTP |
| Calculated MW: | 48kDa |
| Observed MW: | Refer to figures |
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