Antibody Name:	PTMA Antibody (PACO17243)
Antibody SKU:	PACO17243
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Full length fusion protein

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17243(PTMA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17243(PTMA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Prothymosin α (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.

Synonyms:

prothymosin, alpha

UniProt Protein Function:	PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cell cycle regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: transcription, DNA-dependent
UniProt Code:	P06454
NCBI GenInfo Identifier:	135834
NCBI Gene ID:	5757
NCBI Accession:	P06454.2
UniProt Secondary Accession:	P06454,Q15249, Q15592,
UniProt Related Accession:	P06454
Molecular Weight:	12,074 Da
NCBI Full Name:	Prothymosin alpha
NCBI Synonym Full Names:	prothymosin, alpha
NCBI Official Symbol:	PTMA
NCBI Official Synonym Symbols:	TMSA
NCBI Protein Information:	prothymosin alpha
UniProt Protein Name:	Prothymosin alpha
Protein Family:	Prothymosin
UniProt Gene Name:	PTMA
UniProt Entry Name:	PTMA_HUMAN

Antibodies	ELISA Kits
Anti-PTMA Antibody (CAB1956)	Human PTMA / Prothymosin alpha ELISA Kit
PTMA Antibody (PACO11581)	Human Prothymosin alpha (PTMA) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)