Antibody Name:	PSPN Antibody (PACO18431)
Antibody SKU:	PACO18431
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human PSPN

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18431(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18431(PSPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid, similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.

Synonyms:

persephin

UniProt Protein Function:	PSPN: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Belongs to the TGF-beta family. GDNF subfamily.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: extracellular space Molecular Function:growth factor activity; receptor binding Biological Process: nervous system development; axon guidance; central nervous system development; ureteric bud branching
NCBI Summary:	The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]
UniProt Code:	O60542
NCBI GenInfo Identifier:	7531178
NCBI Gene ID:	5623
NCBI Accession:	O60542.1
UniProt Related Accession:	O60542
Molecular Weight:	16,600 Da
NCBI Full Name:	Persephin
NCBI Synonym Full Names:	persephin
NCBI Official Symbol:	PSPN
NCBI Official Synonym Symbols:	PSP
NCBI Protein Information:	persephin
UniProt Protein Name:	Persephin
Protein Family:	Persephin
UniProt Gene Name:	PSPN
UniProt Entry Name:	PSPN_HUMAN

Antibodies	ELISA Kits
PSPN Antibody (PACO01995)	Human Persephin / PSPN ELISA Kit
	Human PSPN (Persephin) CLIA Kit (HUES00932)
	Human Persephin (PSPN) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)