PSMB10 Monoclonal Antibody
- SKU:
- CAB21123
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PSMB10 Monoclonal Antibody |
| Product Code: | CAB21123 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC2999 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Raji, 293T, Mouse liver, Rat lung, Rat spleen, Rat thymus |
| Cellular Location: | Cytoplasm, Nucleus |
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human PSMB10 (P40306). |
| Sequence: | MLKPA LEPRG GFSFE NCQRN ASLER VLPGL KVPHA RKTGT TIAGL VFQDG VILGA DTRAT NDSVV ADKSC EKIHF IAPKI YCCGA GVAAD AEMTT RMVAS KMELH ALSTG REPRV ATVTR ILRQT LFRYQ GHVGA SLIVG GVDLT GPQLY GVHPH GSYSR LPFTA LGSGQ DAALA VLEDR FQPNM TLEAA QGLLV EAVTA GILGD LGSGG NVDAC VITKT GAKLL RTLSS PTEPV KRSGR YHFVP GTTAV LTQTV KPLTL ELVEE TVQAM EVE |
| Synonyms: | LMP10, MECL1, PRAAS5, beta2i |
| Calculated MW: | 29kDa |
| Observed MW: | 25-29kDa |
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