PSMA/FOLH1 Monoclonal Antibody (CAB22211)

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SKU:
CAB22211
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC

Description

Product Name:PSMA/FOLH1 Monoclonal Antibody
Product Code:CAB22211
Reactivity:Human, Mouse
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC56327
Reactivity:Human, Mouse
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:10000-1:40000, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:LNCaP
Cellular Location:cell surface, cytoplasm, extracellular exosome, plasma membrane

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PSMA/FOLH1 (NP_004467.1).
Sequence:TNITP KHNMK AFLDE LKAEN IKKFL YNFTQ IPHLA GTEQN FQLAK QIQSQ WKEFG LDSVE LAHYD VLLSY PNKTH PNYIS IINED GNEIF NTSLF EPPPP G
Synonyms:PSM, FGCP, FOLH, GCP2, PSMA, mGCP, GCPII, NAALAD1
Calculated MW:84kDa
Observed MW:100kDa
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