PSAP Polyclonal Antibody
- SKU:
- CAB21761
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | PSAP Polyclonal Antibody |
| Product Code: | CAB21761 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, HepG2, A-431, Mouse brain, Rat brain |
| Cellular Location: | Lysosome, Secreted |
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human PSAP (NP_002769.1). |
| Sequence: | KEMPM QTLVP AKVAS KNVIP ALELV EPIKK HEVPA KSDVY CEVCE FLVKE VTKLI DNNKT EKEIL DAFDK MCSKL PKSLS EECQE VVDTY GSSIL SILLE EVSPE LVCSM LHLCS GTRLP ALTVH VTQPK DGGFC EVCKK LVGYL DRNLE KNSTK QEILA ALEKG CSFLP DPYQK QCDQF VAEYE PVLIE ILVEV MDPSF VCLKI GACPS AHKPL LGTEK CIWGP SYWCQ NTETA AQCNA VEHCK RHVWN |
| Synonyms: | GLBA, SAP1, SAP2, PSAPD, PARK24 |
| Calculated MW: | 58kDa |
| Observed MW: | 63kDa |
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