Proprotein Convertase 9(PCSK9) Monoclonal Antibody
- SKU:
- CAB21909
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Proprotein Convertase 9(PCSK9) Monoclonal Antibody |
| Product Code: | CAB21909 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC0695 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cell surface, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted |
| Customer Validation: | (小鼠心脏组织) |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human Proprotein Convertase 9(PCSK9) (Q8NBP7). |
| Sequence: | MEAQG GKLVC RAHNA FGGEG VYAIA RCCLL PQANC SVHTA PPAEA SMGTR VHCHQ QGHVL TGCSS HWEVE DLGTH KPPVL RPRGQ PNQCV GHREA SIHAS C |
| Synonyms: | FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC-1, HCHOLA3 |
| Calculated MW: | 74kDa |
| Observed MW: | Refer to figures |
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