PLOD2/LH2 Monoclonal Antibody
- SKU:
- CAB22040
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PLOD2/LH2 Monoclonal Antibody |
| Product Code: | CAB22040 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54359 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:10000-1:30000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-87MG, DU145, Molt-4, Mouse uterus, Rat uterus |
| Cellular Location: | Lumenal side, Peripheral membrane protein, Rough endoplasmic reticulum membrane |
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human PLOD2/LH2 (NP_000926.2). |
| Sequence: | ILLNY FGNYV PNSWT QDNGC TLCEF DTVDL SAVDV HPNVS IGVFI EQPTP FLPRF LDILL TLDYP KEALK LFIHN KEVYH EKDIK VFFDK AKHEI KTIKI VGPEE NLSQA EARNM GMDFC R |
| Synonyms: | LH2, TLH, BRKS2 |
| Calculated MW: | 85kDa |
| Observed MW: | 100kDa |
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