PIM1 Polyclonal Antibody
- SKU:
- CAB24475
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PIM1 Polyclonal Antibody |
| Product Code: | CAB24475 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Rat kidney |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 213-313 of human PIM1 (NP_002639.1). |
| Sequence: | IRYHR YHGRS AAVWS LGILL YDMVC GDIPF EHDEE IIRGQ VFFRQ RVSSE CQHLI RWCLA LRPSD RPTFE EIQNH PWMQD VLLPQ ETAEI HLHSL SPGPS K |
| Synonyms: | PIM1, PIM, serine/threonine-protein kinase pim-1 |
| Calculated MW: | 35kDa/45kDa |
| Observed MW: | 44kDa |
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