Phospho-PLC gamma 1 (PLCG1)-Y783 Monoclonal Antibody

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SKU:
CABP1340
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Phospho-PLC gamma 1 (PLCG1)-Y783 Monoclonal Antibody
Product Code:CABP1340
Reactivity:Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC54936
Reactivity:Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:NIH/3T3
Cellular Location:cell projection, cytoplasm, cytosol, plasma membrane, ruffle membrane

The protein encoded by this gene catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen:A synthetic phosphorylated peptide around Y783 of human Phospho-PLC gamma 1 (PLCG1)-Y783 (NP_877963.1).
Sequence:GFYVE
Synonyms:PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1
Calculated MW:149kDa
Observed MW:155kDa
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